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After 1 and 2 weeks of daily dosing with dutasteride 0. In patients with BPH treated with dutasteride 0. The median increase in serum testosterone was 19% at both 1 and 2 years, 26% at 3 years, and 22% at 4 years, but the mean and median levels remained within the physiologic range. In patients with BPH treated with 5 mg/day of dutasteride or placebo for up to 12 weeks prior to transurethral resection of the prostate, mean DHT concentrations in prostatic tissue were significantly lower in the dutasteride group compared with placebo (784 and 5,793 pg/g, respectively, P P Effects on Other Hormones: In healthy volunteers, 52 weeks of treatment with dutasteride 0. Statistically significant, baseline-adjusted mean increases compared with placebo were observed for total testosterone at 8 weeks (97. There was no change in bone mineral density as measured by dual energy x-ray absorptiometry compared with either placebo or baseline. 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